| 1. | Bone morphogenic proteins ( BMPs ) are important regulators of optic cup development.
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| 2. | The middle portion of the optic cup develops into the ciliary body and iris.
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| 3. | The optic vesicles then begin to form the optic cup.
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| 4. | The final 18 hours involve continuing this apically convex invagination to form the optic cup.
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| 5. | Iris is formed from the optic cup cells.
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| 6. | In 2012, Sasai became the first stem cell researcher to grow an optic cup from human cells.
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| 7. | Interactions between tissues and signaling pathways also play a major role in morphogenesis of the optic cup.
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| 8. | In fact, research studies have shown that BMP agonists and antagonists are necessary for precision of optic cup development.
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| 9. | The " fgf " 8 mRNA becomes localized in what differentiates into the neural retina of the optic cup.
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| 10. | Further differentiation and mechanical rearrangement of cells in and around the optic cup gives rise to the fully developed eye.
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